Podocyte-specific Nox4 deletion affords renoprotection in a mouse model of diabetic nephropathy
نویسندگان
چکیده
منابع مشابه
Renoprotection by Telmisartan versus Benazepril in Streptozotocin Induced Diabetic Nephropathy
Diabetic nephropathy (DN) is one of the major causes of end stage renal disease. Angiotensin converting enzyme (ACE) inhibitor and angiotensin receptor blocker (ARB) are preferred for delaying progression of DN. This study compared the preventive renal effects of telmisartan (10 mg/kg, p.o.), an ARB that completely blocks angiotensin action, and benazepril (5 mg/kg, p.o.), an ACE inhibitor, whi...
متن کاملDPP-4 inhibitors-renoprotection in diabetic nephropathy?
There is no doubt that rates of chronic kidney disease are escalating and that this rise is the main contributor to the increasing prevalence of diabetic nephropathy. It is also clear that the increase in kidney failure continues despite tight blood glucose and blood pressure control, as well as renin-angiotensin system blockade. In response, research into novel therapies to treat diabetic neph...
متن کاملPodocyte-specific overexpression of the antioxidant metallothionein reduces diabetic nephropathy.
Podocytes are critical components of the selective filtration barrier of the glomerulus and are susceptible to oxidative damage. For investigation of the role of oxidative stress and podocyte damage in diabetic nephropathy, transgenic mice that overexpress the antioxidant protein metallothionein (MT) specifically in podocytes (Nmt mice) were produced. MT expression was increased six- and 18-fol...
متن کاملDiabetic nephropathy: evidence for renoprotection and practice.
Patients with diabetic renal disease have a very bad prognosis. Hyperfiltration, related to poor metabolic control, occurs early on in the disease process. There is also an increase in albumin excretion which can be readily reversed by eVective glycaemic control at clinical diagnosis (fig 1). A phase is then entered during which most patients are normoalbuminuric. However, after approximately 1...
متن کاملOptimal dose of losartan for renoprotection in diabetic nephropathy.
BACKGROUND Angiotensin II subtype-1 receptor antagonists represent a valuable new class of drugs in the treatment of diabetic nephropathy. The aim of our study was to evaluate the optimal dose of losartan for renoprotection and blood pressure reduction in diabetic nephropathy. METHODS Fifty consecutive hypertensive type 1 diabetic patients with diabetic nephropathy received increasing doses o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Diabetologia
سال: 2015
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s00125-015-3796-0